Accurate multiple sequence alignment of transmembrane proteins with PSI-Coffee.

TitleAccurate multiple sequence alignment of transmembrane proteins with PSI-Coffee.
Publication TypeJournal Article
Year of Publication2012
AuthorsChang JM, Di Tommaso P, Taly JF, Notredame C
JournalBMC Bioinformatics
Volume13 Suppl 4
PaginationS1
Abstract

Transmembrane proteins (TMPs) constitute about 20 30% of all protein coding genes. The relative lack of experimental structure has so far made it hard to develop specific alignment methods and the current state of the art (PRALINE™) only manages to recapitulate 50% of the positions in the reference alignments available from the BAliBASE2-ref7.

URLhttp://dx.doi.org/10.1186/1471-2105-13-S4-S1
DOI10.1186/1471-2105-13-S4-S1