Metastability of Native Proteins and the Phenomenon of Amyloid Formation.
|Title||Metastability of Native Proteins and the Phenomenon of Amyloid Formation.|
|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Baldwin AJ, Knowles TP, Tartaglia G, Fitzpatrick A, Devlin G, Shammas S, Waudby CA, Mossuto MF, Gras SL, Christodoulou J, Anthony-Cahill SJ, Barker PD, Vendruscolo M, Dobson CM|
|Journal||Journal of the American Chemical Society|
An experimental determination of the thermodynamic stabilities of a series of amyloid fibrils reveals that this structural form is likely to be the most stable one that protein molecules can adopt even under physiological conditions. This result challenges the conventional assumption that functional forms of proteins correspond to the global minima in the free energy surfaces and suggests that living systems are conformationally as well as chemically metastable.