The kinomes of apicomplexan parasites.

TitleThe kinomes of apicomplexan parasites.
Publication TypeJournal Article
Year of Publication2012
AuthorsMiranda-Saavedra D, Gabaldón T, Barton GJ, Langsley G, Doerig C
JournalMicrobes Infect.
Volume14
Pagination796–810
Date PublishedAug
Abstract

Protein phosphorylation plays a fundamental role in the biology of apicomplexan parasites. Many apicomplexan protein kinases are substantially different from their mammalian orthologues, and thus constitute a landscape of potential drug targets. Here, we integrate genomic, biochemical, genetic and evolutionary information to provide an integrated and up-to-date analysis of twelve apicomplexan kinomes. All kinome sequences are available through the Kinomer database.

URLhttp://dx.doi.org/10.1016/j.micinf.2012.04.007
DOI10.1016/j.micinf.2012.04.007