Bioinformatics and Genomics

Group leader:  Roderic Guigó Serra

Research in our group focuses on the investigation of the signals involved in gene specification in genomic sequences (promoter elements, splice sites, translation initiation sites, ...). We are interested both in the mechanism of their recognition and processing, and in their evolution. In addition, but related to this basic component of our research, our group is also involved in the development of software for gene prediction and annotation in genomic sequences. Some of our current projects are:

  • Evaluation of Gene Prediction Programmes
  • Gene Prediction software: geneid
  • Genome-Wide Search for Selenoproteins
  • Gene Prediction by Comparative Genomics
  • Splicing
  • Gene Structure Evolution
  • Phylogenetic Reconstruction

NEW GENEID PARAMETER FILES AVAILABLE

Posted Wed, 2010-07-28 12:38 by Francisco Nuno de Medeiros e Câmara D...

We have recently added three new species-specific parameter files to our ab initio gene predictor (geneid) home page.

"Symposium: The ENCODE project ten years after the human genome sequence"

Posted Tue, 2010-07-27 18:09 by Francisco Nuno de Medeiros e Câmara D...

More than two years into the scaling phase of the ENCODE project, and as one of the active ENCODE research units our group hosted the ENCODE Analysis Working group which met in Barcelona to discuss the challenges of analyzing the great amount of data being produced by the project.

CRG Lab Technician

Posted Fri, 2010-05-14 15:42 by Francisco Nuno de Medeiros e Câmara D...
Reference: 
Ref. BG-BG-TEC-0510

The Bioinformatics and Genomics Group at the Centre for Genomic Regulation are seeking a highly-motivated technician to support its new laboratory. The lab exists within the world-leading Bioinformatics group of Professor Roderic Guigo, and will carry out experiments to complement genome-wide datasets and predictions produced on the computational side. You will be responsible for managing the day-to-day activity of this small laboratory, and supporting various experimental projects on cutting-edge themes.

International network of cancer genome projects: chronic lymphocytic leukemia (CLL)

Posted Tue, 2010-04-27 11:41 by Francisco Nuno de Medeiros e Câmara D...

Our group headed by Roderic Guigó is one of the research units in Spain part of the  International Cancer Genome Consortium (ICGC) .  As all the participating groups in Spain we will be looking into chronic lymphocytic leukemia (CLL) using techniques such as RNASeq. The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe.

Bibliography

Transcriptome genetics using second generation sequencing in a Caucasian population

Posted Mon, 2010-03-15 17:29 by Francisco Nuno de Medeiros e Câmara D...

Micha Sammeth and Roderic Guigó are contributing authors in a recently published Nature letter that looks into how second generation sequencing technologies are now providing unprecedented access to the fine structure of the transcriptome.

Bibliography

Nothing found

GEM hands on

Posted Mon, 2010-02-01 19:29 by Toni Hermoso Pulido

Paolo Ribeca on GEM pratical cases.

GEM library strives to be a true "next-generation" tool for handling any kind of sequence data, offering state-of-the-art algorithms and data structures specifically tailored to this demanding task.

Date

Tue, 2010-02-02 11:00 - 12:00

Seminar - Federica Battistini

Posted Fri, 2010-01-22 18:25 by Romina Garrido Enamorado

Federica Batisttini, a post-doc candidate for Roderic's lab is giving a seminar on Feb 1 at 10:00 h at room Aula (473.10).

 

Sequence Selectivity of DNA Wrapping in the Nucleosome

Date

Mon, 2010-02-01 10:00 - 11:00

Exon Wrap

Posted Fri, 2009-09-18 10:24 by Roderic Guigó Serra

By comparing exon-intron position in higher eukaryotes to available large scale nucleosome positioning datasets, we have find that exons tend to have higher nucleosome occupancy than introns (Tilgner et al., NSMB 2009)

Bibliography

Group photo
Annual Group Photo 2008 - Bioinformatics and Genomics
Annual Group Photo 2008 - Bioinformatics and Genomics
preferential positioning of nucleosomes on exonic DNA
screenshot of the SECISaln web-based server at the BGL
Predictions obtained by the ab intion program GeneID in genomic region of Drosophila melanogaster
Eukaryotic SECIS element consensus sequence
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