In an article published online in Nature, we validated the hypothesis that compensatory interactions allow most protein sequences, even the most conservative ones, to maintain the same function while diverging in sequence almost without limit.

A review article detailing and contrasting different theories on the evolution of gene duplications has been published online in Nature Reviews Genetics. In this article we present the modern state of the theory of duplicated genes and provide concrete recommendations for future experiments that may do a better job at elucidating the selective mechanisms at work in the evolution of duplicated genes.