Evolution of the eukaryotic cell: mitochondria and peroxisomes
Every eukaryotic organism shows a high level of sub-cellular compartmentalization that is significantly more intricate than the most complex prokaryotic cell. How such degree of complexity came to be is still not fully understood. In this context, endo-symbiotic events with bacterial organisms have been proposed to be the source of a number of organelles including mitochondria, chloroplasts and peroxisomes. Only recently, it has been possible to contrast these hypotheses with the growing availability of completely sequenced genomes and organellar proteomic data. We use large-scale evolutionary analyses to investigate the origin and evolution two most widespread organelles for which an endosymbiotic origin has been proposed: mitochondria and peroxisomes.
From endosymbiont to host-controlled organelle: the hijacking of mitochondrial protein synthesis and metabolism.. PLoS Comput. Biol.. 3:e219.. 2007.