Publications - Gene Function and Evolution

Info about publications

2012

Speretta, E, Jahn TR, Tartaglia GG, Favrin G, Barros TP, Imarisio S, Lomas DA, Luheshi LM, Crowther DC, Dobson CM.  2012.  Expression in Drosophila of Tandem Aβ Peptides Provides Insights Into the Link Between Aggregation and Neurotoxicity. J Biol Chem.
Pubmed
Calloni, G, Chen T, Schermann SM, Chang H, Genevaux P, Agostini F, Tartaglia GG, Hayer-Hartl M, Hartl FU.  2012.  DnaK Functions as a Central Hub in the E. coli Chaperone Network. Cell Reports.

2011

Agostini, F, Vendruscolo M, Tartaglia GG.  2011.  Sequence-based prediction of protein solubility. Journal of Molecular Biology.
Murakami, T, Yang SP, Xie L, Kawano T, Fu D, Mukai A, Bohm C, Chen F, Robertson J, Suzuki H et al..  2011.  ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism. Hum Mol Genet. Abstract
Pubmed
Baldwin, AJ., Knowles TP., Tartaglia G, Fitzpatrick A, Devlin G, Shammas S, Waudby CA., Mossuto MF., Gras SL., Christodoulou J et al..  2011.  Metastability of Native Proteins and the Phenomenon of Amyloid Formation.. Journal of the American Chemical Society. Abstract
Pubmed
Bellucci, M, Agostini F, Masin M, Tartaglia GG.  2011.  Predicting protein associations with long noncoding RNAs. Nat. Methods. 8:444–445.
Pubmed
Mossuto, MF, Bolognesi B, Guixer B, Dhulesia A, Agostini F, Janet R, Kumita JR, Tartaglia GG, Dumoulin M, Dobson CM et al..  2011.  Disulfide bonds reduce the toxicity of the amyloid fibrils formed by an extracellular protein. Angew Chem Intl Ed.
Jahn, TR., Kohloff KJ., Scott M, Tartaglia GG., Lomas DA., Dobson CM., Vendruscolo M, Crowther DC..  2011.  Detection of Early Locomotor Abnormalities in a Drosophila Model of Alzheimer's Disease.. Journal of Neuroscience Methods.
Olzscha, H, Schermann SM., Woerner AC., Pinkert S, Hecht MH., Tartaglia GG., Vendruscolo M, Hayer-Hartl M, Hartl FU., Vabulas RM..  2011.  Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions.. Cell. Abstract
Pubmed
Raimondi, S, Guglielmi F, Giorgetti S, Di Gaetano S, Arciello A, Monti M, Relini A, Nichino D, Doglia AM., Natalello A et al..  2011.  Effects of the known pathogenic mutations on the aggregation pathway of the amyloidogenic peptide of Apolipoprotein A-I. J. Mol. Biol..

2010

Tartaglia, GG., Vendruscolo M.  2010.  Proteome-level interplay between folding and aggregation propensities of proteins.. J. Mol. Biol.. 402:919–928. Abstract
Pubmed
Brorsson, AC., Bolognesi B, Tartaglia GG., Shammas SL., Favrin G, Watson I, Lomas DA., Chiti F, Vendruscolo M, Dobson CM. et al..  2010.  Intrinsic determinants of neurotoxic aggregate formation by the amyloid beta peptide.. Biophys. J.. 98:1677–1684. Abstract
Pubmed
Tartaglia, GG., Dobson CM., Hartl FU., Vendruscolo M.  2010.  Physicochemical determinants of chaperone requirements.. J. Mol. Biol.. 400:579–588. Abstract
Pubmed
Szczepankiewicz, O, Cabaleiro-Lago C, Tartaglia GG., Vendruscolo M, Hunter T, Hunter GJ., Nilsson H, Thulin E, Linse S.  2010.  Interactions in the native state of monellin, which play a protective role against aggregation.. Molecular bioSystems. Abstract
Pubmed
Lee, Y, Zhou T, Tartaglia GG., Vendruscolo M, Wilke CO..  2010.  Translationally optimal codons associate with aggregation-prone sites in proteins.. Proteomics. Abstract
Pubmed

2009

Hamada, D, Tanaka T, Tartaglia GG., Pawar A, Vendruscolo M, Kawamura M, Tamura A, Tanaka N, Dobson CM..  2009.  Competition between folding, native-state dimerisation and amyloid aggregation in beta-lactoglobulin.. J. Mol. Biol.. 386:878–890. Abstract
Pubmed
Calamai, M, Tartaglia GG., Vendruscolo M, Chiti F, Dobson CM..  2009.  Mutational analysis of the aggregation-prone and disaggregation-prone regions of acylphosphatase.. J. Mol. Biol.. 387:965–974. Abstract
Pubmed
Routledge, KE., Tartaglia GG., Platt GW., Vendruscolo M, Radford SE..  2009.  Competition between intramolecular and intermolecular interactions in an amyloid-forming protein.. J. Mol. Biol.. 389:776–786. Abstract
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Tartaglia, GG., Pechmann S, Dobson CM., Vendruscolo M.  2009.  A relationship between mRNA expression levels and protein solubility in E. coli.. J. Mol. Biol.. 388:381–389. Abstract
Pubmed
Buell, AK., Tartaglia GG., Birkett NR., Waudby CA., Vendruscolo M, Salvatella X, Welland ME., Dobson CM., Knowles TP..  2009.  Position-dependent electrostatic protection against protein aggregation.. Chembiochem. 10:1309–1312. Abstract
Pubmed
Yanamandra, K, Alexeyev O, Zamotin V, Srivastava V, Shchukarev A, Brorsson AC., Tartaglia GG., Vogl T, Kayed R, Wingsle G et al..  2009.  Amyloid formation by the pro-inflammatory S100A8/A9 proteins in the ageing prostate.. PLoS ONE. 4:e5562. Abstract
Pubmed
Pechmann, S, Levy ED., Tartaglia GG., Vendruscolo M.  2009.  Physicochemical principles that regulate the competition between functional and dysfunctional association of proteins.. Proc. Natl. Acad. Sci. U.S.A.. 106:10159–10164. Abstract
Pubmed
Tartaglia, GG., Vendruscolo M.  2009.  Correlation between mRNA expression levels and protein aggregation propensities in subcellular localisations.. Mol Biosyst. 5:1873–1876. Abstract
Pubmed

2008

Tartaglia, GG., Vendruscolo M.  2008.  The Zyggregator method for predicting protein aggregation propensities.. Chem Soc Rev. 37:1395–1401. Abstract
Pubmed
Rivers, RC., Kumita JR., Tartaglia GG., Dedmon MM., Pawar A, Vendruscolo M, Dobson CM., Christodoulou J.  2008.  Molecular determinants of the aggregation behavior of alpha- and beta-synuclein.. Protein Sci.. 17:887–898. Abstract
Pubmed
Vendruscolo, M, Tartaglia GG..  2008.  Towards quantitative predictions in cell biology using chemical properties of proteins.. Mol Biosyst. 4:1170–1175. Abstract
Pubmed

2007

Tartaglia, GG., Caflisch A.  2007.  Computational analysis of the S. cerevisiae proteome reveals the function and cellular localization of the least and most amyloidogenic proteins.. Proteins. 68:273–278. Abstract
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Tartaglia, GG., Cavalli A, Vendruscolo M.  2007.  Prediction of local structural stabilities of proteins from their amino acid sequences.. Structure. 15:139–143. Abstract
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Meehan, S, Knowles TP., Baldwin AJ., Smith JF., Squires AM., Clements P, Treweek TM., Ecroyd H, Tartaglia GG., Vendruscolo M et al..  2007.  Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human alphaA-, alphaB- and R120G alphaB-crystallins.. J. Mol. Biol.. 372:470–484. Abstract
Pubmed
Luheshi, LM., Tartaglia GG., Brorsson AC., Pawar AP., Watson IE., Chiti F, Vendruscolo M, Lomas DA., Dobson CM., Crowther DC..  2007.  Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity.. PLoS Biol.. 5:e290. Abstract
Pubmed
Meinhardt, J, Tartaglia GG., Pawar A, Christopeit T, Hortschansky P, Schroeckh V, Dobson CM., Vendruscolo M, F√§ndrich M.  2007.  Similarities in the thermodynamics and kinetics of aggregation of disease-related Abeta(1-40) peptides.. Protein Sci.. 16:1214–1222. Abstract
Pubmed
Monsellier, E, Ramazzotti M, de Laureto PP., Tartaglia GG., Taddei N, Fontana A, Vendruscolo M, Chiti F.  2007.  The distribution of residues in a polypeptide sequence is a determinant of aggregation optimized by evolution.. Biophys. J.. 93:4382–4391. Abstract
Pubmed
Tartaglia, GG., Pechmann S, Dobson CM., Vendruscolo M.  2007.  Life on the edge: a link between gene expression levels and aggregation rates of human proteins.. Trends Biochem. Sci.. 32:204–206.
Pubmed

2005

Tartaglia, GG., Cavalli A, Pellarin R, Caflisch A.  2005.  Prediction of aggregation rate and aggregation-prone segments in polypeptide sequences.. Protein Sci.. 14:2723–2734. Abstract
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Tartaglia, GG., Pellarin R, Cavalli A, Caflisch A.  2005.  Organism complexity anti-correlates with proteomic beta-aggregation propensity.. Protein Sci.. 14:2735–2740. Abstract
Pubmed

2004

Feng, J, Tartaglia GG., Tirozzi B.  2004.  A note on minimum variance theory and beyond.. J. Phys. A Mat.. :4685-4700. Abstract
Tartaglia, GG., Cavalli A, Pellarin R, Caflisch A.  2004.  The role of aromaticity, exposed surface, and dipole moment in determining protein aggregation rates.. Protein Sci.. 13:1939–1941. Abstract
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