Constitutive patterns of gene expression regulated by RNA-binding proteins

 

 

RNA-binding proteins regulate a number of cellular processes, including synthesis, folding, translocation, assembly and clearance of RNAs. Recent studies have reported that an unexpectedly large number of proteins are able to interact with RNA, but partners of many RNA-binding proteins are still uncharacterized. 

In a recent publication [1], we combined prediction of ribonucleoprotein interactions, based on catRAPID calculations, with analysis of protein and RNA expression profiles from human tissues. We found strong interaction propensities for both positively- and negatively-correlated expression patterns. Our integration of in silico and ex vivo data unraveled two major types of protein-RNA interactions, with positively-correlated patterns related to cell cycle control and negatively- correlated patterns related to survival, growth and differentiation. 

Our analysis sheds light on the role of RNA-binding proteins in regulating proliferation and differentiation processes, and we provide a data exploration tool to aid the design of future experimental studies.

  [1] http://www.ncbi.nlm.nih.gov/pubmed/24401680page2image19064 page2image19224 page2image19648 page2image19808 page2image19968 page2image20128 page2image20288 page2image20448 page2image20608 page2image20768 page2image20928 page2image21088 page2image21248 page2image21408 page2image21568 page2image21728 page2image21888 page2image22048 page2image22208 page2image22368 page2image22528 page2image22688 page2image22848 page2image23008 page2image23168 page2image23328 page2image23488