Gene Function and Evolution

Group leader:  Gian Gaetano Tartaglia
Predictions of Interactomes and Evolution of Proteomes

 

X CRG Annual Symposium "Computational Biology of Molecular Sequences" (10-11 November 2011)

On the 10-11 of November 2011 our group headed by Roderic Guigo will be organizing a two-day CRG symposium on “Computational Biology of Molecular Sequences” which will bring together renowned Computational Biologists from around the world, including both pioneers in the field, as well as promising young scientists. Presentations, discussions and dialogue during the Symposium will contribute to survey the status of a discipline that, at the intersection of Biology and Computation, will have an enormous impact on the world of the XXIst century.

You may obtain more information on the objectives of the symposium, the current list of confirmed speakers and instructions on how to register by clicking here. The poster of the symposium can be downloaded by clicking here.

MetaPhOrs: orthologs and paralogs accross 829 genomes, based on multiple phylogenetic evidence

We have launched MetaPhOrs, a meta-method to predict orthology and paralogy from multiple phylogenetic evidence. To maximize reliability and coverage, we retrieved gene trees from PhylomeDB, Ensembl, TreeFam and Orthogroups. In addition we built maximum likelihood trees for orthologous gene families in OrthoMCL, COG, and EggNOG.

Bibliography

PhylomeDB v3.0 released

A new version of PhylomeDB has been released. With over 400.000 phylogenetic trees, PhylomeDB is currently the major public phylogenetic repository. It contains phylomes from model (Human, Yeast, Drosophila, Arabidopsis), but also alternative models such as the fungal pathogen Candida albicans, or the insects T. castaneum, N. vitripenis  and A. pisum.  New features have been added to the user's front end, including fully interactive tree images and link outs to external information.

Bibliography

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IX CRG Annual Symposium (Medical Genome Sequencing: Understanding the genomes of disease)

This symposium was organized by Roderic Guigo and Xavier Estivill and held on the 28-29 Oct 2010. It aimed at establishing a forum for capturing the latest advances in genomic sequencing technologies and its various medical applications. The two-day meeting featured talks by international keynote speakers outlining the current status of medical sequencing, and putting forth the technological challenges ahead. More information on this past event can be obtained by clicking here.

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