Development of methods to analyze the relationship between chromatin and splicing

The search of sequence prerequisites for nucleosome positioning has been a long-standing problem at the intersection of chromatin structure and gene regulation. With the use of structural information directly related to the primary DNA sequence we propose a new property of natural nucleosome forming sequences, which is inherently related to their intrinsic curvature and its symmetry.

Methods for RNAseq (NGS) data analysis

The field of transcriptomics has recently been given a huge boost from the use of “second” generation high throughput sequencing technologies to sequence RNA samples. Second generation sequencing technologies provide an unprecedented capacity for surveying the nucleic acid content of cells.

Computational Biology of RNA Processing

Group leader:  Roderic Guigó
Investigation of sequence patterns in the genome responsible for functionality

Research in our group focuses on the investigation of the signals involved in gene specification in genomic sequences (promoter elements, splice sites, translation initiation sites, etc…). We are interested both in the mechanism of their recognition and processing, and in their evolution. In addition, but related to this basic component of our research, our group is also involved in the development of software for gene prediction and annotation in genomic sequences.

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